YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations
نویسندگان
چکیده
Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells.
منابع مشابه
Oncogenic GNAQ and GNA11 Mutations in Uveal Melanoma in Chinese
PURPOSE To examine whether GNAQ and GNA11 somatic mutations previously identified in uveal melanomas of Caucasians are associated with uveal melanomas in Chinese patients. METHODS Uveal melanomas treated by primary enucleation in Chinese patients underwent a mutation analysis of GNAQ and GNA11 with sequencing of exon 5 and exon 4. RESULTS The study included 50 patients with uveal melanoma a...
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